BD Clinical Research Team
The BD Clinical Research Services (CRS) team has published manuscripts on a number of topics using the BD Clinical Research Databases, many of which have been presented in numerous national and international conferences, and some of which are shown here.
Manuscripts Published in Peer-Reviewed Journals (CRS Team Members in Bold):
- Puzniak L, DePestel DD, Srinivasan A, Ye G, Murray J, Merchant S, DeRyke CA, Gupta V. A Combination Antibiogram Evaluation for Pseudomonas aeruginosa in Respiratory and Blood Sources from Intensive Care Unit (ICU) and Non-ICU Settings in U.S. Hospitals. Accepted for publication in Antimicrobial Agents and Chemotherapy. https://aac.asm.org/content/early/2019/01/24/AAC.02564-18
- Tabak YP, Sung AH, Ye G, Vankeepuram L, Gupta V, McCann E. Attributable Clinical and Economic Burden of Carbapenem-Nonsusceptible Gram-Negative Infections in Patients Hospitalized With Complicated Urinary Tract Infections. Accepted for publication in Journal of Hospital Infection. https://www.journalofhospitalinfection.com/article/S0195-6701(18)30673-X/abstract
- McCann E, Srinivasan A, DeRyke CA, Ye G, DePestel DD, Murray J, Gupta V. Carbapenem-Nonsusceptible Gram-Negative Pathogens in ICU and Non-ICU Settings in US Hospitals in 2017: A Multicenter Study. Open Forum Infectious Diseases, Volume 5, Issue 10, 1 October 2018, ofy241, https://doi.org/10.1093/ofid/ofy241
- Tabak YP, Vankeepuram L, Ye G, Jeffers K, Gupta V, Murray PR. Blood Culture Turnaround Time in US Acute Care Hospitals and Implications for Laboratory Process Optimization. Accepted for publication in Journal of Clinical Microbiology: DOI: 10.1128/JCM.00500-18 https://jcm.asm.org/content/56/12/e00500-18
- Gross AE, Johannes RS, Gupta V, Tabak YP, Srinivasan A, & Bleasdale SC. The effect of a piperacillin/tazobactam shortage on antimicrobial prescribing and Clostridium difficile risk in 88 medical centers. Clin Infect Dis. 2017 Aug 15;65(4):613-618. doi: 10.1093/cid/cix379. https://www.ncbi.nlm.nih.gov/pubmed/28444166
- Maddox RR, Oglesby HJA, Tabak YP, Johannes RS. Improving Mechanical Ventilation Management Process Aided with an Analytics Informatics System in the Intensive Care Units. In press. PDF - https://www.respiratorytherapy.ca/pdf/RT-12-4-Fall-2017-R16-web.pdf
- Tabak YP, Sun X, Nunez CM, Gupta V, Johannes RS. Predicting Readmission at Early Hospitalization Using Electronic Clinical Data: An Early Readmission Risk Score. Med Care. 2017 Mar; 55(3):267-275. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318151/
- Tabak YP, Johannes RS, Sun X, Crosby CT, Jarvis WR. Innovative use of existing public and private data sources for post-marketing surveillance of central line-associated bloodstream infections associated with intravenous needleless connectors. J Infus Nurs. 2016 Sep-Oct; 39(5):328-35. https://www.ncbi.nlm.nih.gov/pubmed/27598072
- Ridgway JP,
Sun X, Tabak YP, Johannes RS, Robicsek A. Performance characteristics and associated outcomes for an automated surveillance tool for blood stream infection. Am J Infect Control. 2016 May 1;44(5):567-71. https://www.ncbi.nlm.nih.gov/pubmed/26899530
- Tabak YP, Johannes RS, McDonald LC. A Potential cellular explanation for the increased risk of Clostridium difficile infection due to hypoalbuminemia: A response to Di Bella S. et al. Infect Control Hosp Epidemiol. 2015 Dec; 36(12):1480. https://www.ncbi.nlm.nih.gov/pubmed/26456896
- Tabak YP, Johannes RS, Sun X, Nunez CM, McDonald LC. Predicting the risk for hospital- onset Clostridium difficile infection (HO-CDI) at the time of inpatient admission: HO-CDI Risk Score. Infect Control Hosp Epidemiol. 2015 Mar 10:1-7. https://www.ncbi.nlm.nih.gov/pubmed/25753106
- Tabak YP, Jarvis WR, Sun X, Crosby CT, Johannes RS. Meta-analysis on central line-associated bloodstream infections associated with a needleless intravenous connector with a new engineering design. Am J Infect Control. 2014;42(12):1278-84. https://www.ncbi.nlm.nih.gov/pubmed/25465257
- Tabak YP, Sun X, Nunez CM, Johannes RS. Using electronic health record data to develop inpatient mortality predictive model: Acute Laboratory Risk of Mortality Score (ALaRMS). J Am Med Inform Assoc. 2014;21(3):455-63. https://www.ncbi.nlm.nih.gov/pubmed/24097807
- Tabak YP, Zilberberg MD, Johannes RS, Sun X, McDonald LC. Attributable burden of hospital-onset Clostridium difficile infection: a propensity score matching study. Infect Control Hosp Epidemiol. 2013;34(6):588-96. https://www.ncbi.nlm.nih.gov/pubmed/23651889
- Tabak YP, Sun X, Johannes RS, Hyde L, Shorr AF, Lindenauer PK. Development and validation of a mortality risk-adjustment model for patients hospitalized for exacerbations of chronic obstructive pulmonary disease. Med Care. 2013;51(7):597-605. https://www.ncbi.nlm.nih.gov/pubmed/23604015
- Tabak YP, Sun X, Hyde L, Yaitanes A, Derby K, Johannes RS. Using enriched observational data to develop and validate age-specific mortality risk adjustment models for hospitalized pediatric patients. Med Care. 2013;51(5):437-45. https://www.ncbi.nlm.nih.gov/pubmed/23552435
- Shorr AF, Sun X, Johannes RS, Derby KG, Tabak YP. Predicting the need for mechanical ventilation in acute exacerbations of chronic obstructive pulmonary disease: Comparing the CURB-65 and BAP-65 scores. J Crit Care. 2012;27(6):564-70. https://www.ncbi.nlm.nih.gov/pubmed/22520489
- Shorr AF, Zilberberg MD, Sun X, Johannes RS, Gupta V, Tabak YP. Severe acute hypertension among inpatients admitted from the emergency department. J Hosp Med. 2012;7(3):203-10. https://www.ncbi.nlm.nih.gov/pubmed/22038891
- Lipsky BA, Weigelt JA, Sun X, Johannes RS, Derby KG, Tabak YP. Developing and validating a risk score for lower-extremity amputation in patients hospitalized for a diabetic foot infection. Diabetes Care. 2011;34(8):1695-700. https://www.ncbi.nlm.nih.gov/pubmed/21680728
- Saltzman JR, Tabak YP, Hyett BH, Sun X,
Travis AC, Johannes RS. A simple risk score accurately predicts in-hospital mortality, length of stay, and cost in acute upper GI bleeding. Gastrointest Endosc. 2011;74(6):1215-24. https://www.ncbi.nlm.nih.gov/pubmed/21907980
- Zilberberg MD, Tabak YP, Sievert DM, Derby KG, Johannes RS, Sun X, McDonald LC. Using Electronic Health Information to Risk-Stratify Rates of Clostridium difficile Infection in US Hospitals Infection Control and Hospital Epidemiology 2011;32(7):649-655. https://www.ncbi.nlm.nih.gov/pubmed/21666394
- Shorr AF,
Tabak YP, Johannes RS, Gupta V, Saltzberg MT, Spalding J, Costanzo MR. Burden of Sodium Abnormalities in Patients Hospitalized for Heart Failure. Congest Heart Fail 2011;17:1-7. https://www.ncbi.nlm.nih.gov/pubmed/21272220
- Amarasingham R, Moore BJ, Tabak YP, Drazner MH, Clark CA, Zhang S, Reed WG, Swanson TS, Ma Y, Halm EA. An automated model to identify heart failure patients at risk for 30-day readmission or death using electronic medical record data. Med Care. 2010;48(11):981-8. https://www.ncbi.nlm.nih.gov/pubmed/20940649
- Lipsky BA, Kollef MH, Miller LG, Sun X, Johannes RS, Tabak YP. Predicting bacteremia among patients hospitalized for skin and skin-structure infections: derivation and validation of a risk score. Infect Control Hosp Epidemiol. 2010;31(8):828-37. https://www.ncbi.nlm.nih.gov/pubmed/20586653
- Tabak YP, Sun X, Liu Y, Kurtz SG, Derby K, & Johannes RS. Development and Validation of a Cost-Effective Risk Adjustment System Using Automated Clinical Data. Health Services Research, 2010;45(6 Pt 1):1815-35. https://www.ncbi.nlm.nih.gov/pubmed/21839900
- Lipsky BA, Kollef MH, Miller L, Sun, X, Johannes RS, Tabak, YP. Predicting blood stream infection (BSI) among patients hospitalized for skin and structural tissue infections (SSTI): Derivation and validation of a risk score. Infection Control and Hosp Epidemiology 2010;31(8):828-837. https://www.ncbi.nlm.nih.gov/pubmed/20586653
- Karazogian R, Johannes RS, Sun X, Burakoff R. Increased Mortality and Length of Stay Among Patients With Inflammatory Bowel Disease and Hospital-Acquired Infections. Clin Gastroenterol Heptol
2010;8:961–965. https://www.ncbi.nlm.nih.gov/pubmed/20723618
- : Lipsky BA, Tabak YP, Johannes RS, Vo L, Hyde L, Weigelt JA. Skin and soft tissue infection in hospitalised patients with diabetes: culture isolates and risk factors associated with mortality, length of stay, and cost. Diabetologia. 2010;53(5):914-23. https://www.ncbi.nlm.nih.gov/pubmed/20146051
- Weigelt JA, Lipsky BA, Tabak YP, Derby KG, Myoung Kim, Gupta V. Surgical site infections: causative pathogens and associated outcomes among hospitalized patients, 2003 to 2007. Am J Infect Control. 2010;38(2):112-20. https://www.ncbi.nlm.nih.gov/pubmed/19889474
- Tabak YP, Sun X, Johannes RS, Gupta V, Shorr AF. Mortality and need for mechanical ventilation in acute exacerbations of chronic obstructive pulmonary disease: development and validation of a simple risk score. Arch Intern Med 2009;169(17):1595-1602. https://www.ncbi.nlm.nih.gov/pubmed/19786679
- Shorr AF, Gupta V, Sun X, Johannes RS, Spalding J. Tabak YP. Burden of early-onset candidemia: analysis of culture-positive bloodstream infections from a large US database. Crit Care Med 2009;37(9):2519-2526. https://www.ncbi.nlm.nih.gov/pubmed/19623050
- Shorr AF, Tabak YP, Johannes RS, Sun X, Spalding J, Kollef MH. Candidemia on presentation to the hospital: development and validation of a risk score. Crit Care 2009;13(5):R156 https://www.ncbi.nlm.nih.gov/pubmed/19623050 .
- Singh VK, Wu BU, Bollen TL, Repas K, Maurer R, Johannes RS, Mortele KJ, Conwell DL, Banks PA. A prospective evaluation of the bedside index for severity in acute pancreatitis score in assessing mortality and intermediate markers of severity in acute pancreatitis. Am J Gastroenterol
2009;104(4):966-71. https://www.ncbi.nlm.nih.gov/pubmed/19293787
- Wu BU, Johannes RS, Sun X, Conwell DL, Banks PA. Early changes in blood urea nitrogen predict mortality in acute pancreatitis. Gastroenterology
2009;137(1):129-35. https://www.ncbi.nlm.nih.gov/pubmed/19344722
- Hollenbeak CS, Gorton CP, Tabak YP, Jones JL, Milstein A, Johannes RS. Reductions in mortality associated with intensive public reporting of hospital outcomes. Am J Med Qual 2008;23(4):279-86. https://journals.sagepub.com/doi/abs/10.1177/1062860608318451
- Wu BU, Johannes RS, Sun X, Tabak Y, Conwell DL, Banks PA. The early prediction of mortality in acute pancreatitis: a large population-based study. Gut 2008;57(12):1698-1703. https://www.ncbi.nlm.nih.gov/pubmed/18519429
- Brossette SE, Hymel PA Jr. Data mining and infection control. Clin Lab Med 2008;28:119-126. https://www.ncbi.nlm.nih.gov/pubmed/18194722
- Kilgore ML, Ghosh K, Beavers CM, Wong DY, Hymel PA Jr, Brossette SE. The costs of nosocomial infections. Med Care 2008;46:101-104. https://www.ncbi.nlm.nih.gov/pubmed/18162862
- Ayanian JZ, Sequist TD, Zaslavsky AM,Johannes RS. Physician reminders to promote surveillance for colorectal adenomas: a randomized controlled trial. J Gen Intern Med 2008;23(6):762-7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517870/
- Johannes RS, Peng MM, Darin R. Commentary: Diagnosis Related Group perturbation: a new twist on the economics of hospital-acquired infection? Am J Med Qual 2008;Dec 10:1-3. https://www.ncbi.nlm.nih.gov/pubmed/19073940
- Johannes RS. Epidemiology of early-onset bloodstream infection and implications for treatment. Am J Infect Control 2008;36(10):S171.e13-7. https://www.ncbi.nlm.nih.gov/pubmed/19084147
- MR, Johannes RS, Pine M, Gupta V, Saltzberg M, Hay J, Yancy CW, Fonarow GC. The safety of intravenous diuretics alone vs. diuretics plus parenteral vasoactive therapies in hospitalized patients with acutely decompensated heart failure: A propensity score and instrumental variable analysis using the ADHERE database. American Heart Journal 2007;154:267-277. https://www.ncbi.nlm.nih.gov/pubmed/17643575
- Tabak YP, Johannes RS, Silber, JH. Using automated clinical data for risk adjustment: development and validation of six disease-specific mortality predictive models for pay-for-performance. Medical Care
2007;45:789-805. https://www.ncbi.nlm.nih.gov/pubmed/17667314
- Lipsky BA, Weigelt JA, Gupta V, Killian AK, Peng MP. Skin, soft tissue, bone and joint infections in hospitalized patients: Epidemiology, microbiology, clinical and economic outcomes. Infection Control and Hospital Epidemiology 2007;28:1290-1298. https://www.ncbi.nlm.nih.gov/pubmed/17926281
- Shorr AF, Tabak YP, Killian AD, Gupta V, Liu LZ, Kollef MH. Healthcare-associated bloodstream infection: a distinct entity? Insights from a large US database. Crit Care Med 2006;34:2588–2595. https://www.ncbi.nlm.nih.gov/pubmed/16915117
- Shorr AF, Tabak YP, Gupta V, Johannes RS, Liu LZ, Kollef MH. Morbidity and cost burden of methicillin resistant Staphylococcus aureus in early onset ventilator-associated pneumonia. Critical Care 2006;10(3):R97. https://www.ncbi.nlm.nih.gov/pubmed/16808853
- Killian AD, Gupta V, Goetz AE. Cost analysis of erythropoietic-stimulating therapy dosing in oncology inpatients. Ann Pharmacother 2006;40:421-426. https://www.ncbi.nlm.nih.gov/pubmed/16507613
- Brossette SE, Hacek DM, Gavin PJ, Kamdar MA, Gadbois KD, Fisher AG, Paterson LR. A laboratory-based, hospital-wide, electronic marker for nosocomial infection. The future of infection control surveillance? Am J Clin Pathol 2006;125:34-39. https://www.ncbi.nlm.nih.gov/pubmed/16482989
- Peng M, Kurtz S, R.S. Johannes. The adverse outcomes from hospital acquired infection in Pennsylvania cannot be attributed to increased risk on admission. Am J Med Qual 2006;21[suppl 2]:1-12. https://www.ncbi.nlm.nih.gov/pubmed/17077415
- Kollef MH, Shorr AF, Tabak YP, Gupta V, Liu LZ, Johannes RS. Epidemiology and outcomes of healthcare-associated pneumonia: results from a large US database of culture-positive pneumonia. Chest 2005;128:3854-3862. https://www.ncbi.nlm.nih.gov/pubmed/16354854
- Peterson LR, Hacek DM, Rolland D, Brossette SE. Detection of a community infection outbreak with virtual surveillance. Lancet
2003;362:1587-1588. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(03)14765-4/fulltext
- Peterson LR, Brossette SE. Hunting health care-associated infections from the clinical microbiology laboratory: passive, active, and virtual surveillance. J Clin Microbiol 2002;40:1-4. https://www.ncbi.nlm.nih.gov/pubmed/11773083
- Brossette SE, Sprague AP, Jones WT, Moser SA. A data mining system for infection control surveillance. Methods Inf Med 2000;39:303-310. https://www.ncbi.nlm.nih.gov/pubmed/11191698
- Moser SA, Jones WT, Brossette SE. Application of data mining to intensive care unit microbiologic data. Emerg Infect Dis 1999;5:454-457. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640757/
- Brossette SE, Sprague AP, Hardin JM, Waites KB, Jones WT, Moser SA. Association rules and data mining in hospital infection control and public health surveillance. J Am Med Inform Assoc 1998;5:373-381. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC61314/